He had to laugh despite himself.

他不想笑，但还是忍不住笑了出来。

《牛津词典》

And despite himself, my friend began to relax.

我朋友不由自主地开始放松了。

youdao

Lehrer says he has taken all this on board, and despite his inherent shyness, when he's sitting next to strangers on a plane or at a conference, forces himself to initiate conversations.

莱勒说，他把这些都带到了飞机上。尽管他天生腼腆，但在飞机上或会议上坐在陌生人旁边时，他会强迫自己主动交谈。

youdao

What is clear is that Arnold Schwarzenegger, despite positioning himself as an eco-friendly Republican-lite governor, has no intention of lending a meaty hand.

ECONOMIST: The row over severance

Despite paying himself a small fortune and bullying his employees, Mr Geneen (who worked a 70-hour week and seemed to live off hamburgers) inspired considerable loyalty among his staff.

ECONOMIST: Harold Geneen

"Despite eventually handing himself in, he continued to deny responsibility which brought further grief to Judith's family".

BBC: Bristol man jailed for murder of teacher Judith Ege