He had to laugh despite himself.

他不想笑，但还是忍不住笑了出来。

《牛津词典》

And despite himself, my friend began to relax.

我朋友不由自主地开始放松了。

youdao

Despite himself he looked down again at the gaping mouth of the cadaver.

他的眼光不由自主地又落到了死人张大的嘴上。

youdao

What is clear is that Arnold Schwarzenegger, despite positioning himself as an eco-friendly Republican-lite governor, has no intention of lending a meaty hand.

ECONOMIST: The row over severance

Despite paying himself a small fortune and bullying his employees, Mr Geneen (who worked a 70-hour week and seemed to live off hamburgers) inspired considerable loyalty among his staff.

ECONOMIST: Harold Geneen

"Despite eventually handing himself in, he continued to deny responsibility which brought further grief to Judith's family".

BBC: Bristol man jailed for murder of teacher Judith Ege