The challenge for a person with a depressed spouse, relative or close friend who refuses to get treatment is how to change that defiant person's mind.

如果你的配偶、亲属或密友患有抑郁症却拒绝治疗，那么对你来说最大的挑战莫过于学会如何去改变他们这种抗拒治疗的态度。

youdao

That went against Ms Rousseff's express wishes, and was a defiant challenge to Mr Palocci, who had threatened the party with ministerial sackings should its deputies rebel.

ECONOMIST: Brazil's president