A white colony mutant, 1-40-271, was normal in sporulation and spore germination, but defective in appressorium development and totally lost in pathogenicity.

突变体1-40-271菌落呈白色，产孢与萌发均正常，但萌发后即便在人工疏水表面上也不能形成附着胞，且丧失了致病性；

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The discovery could lead to development of drugs that target the defective gene, said the researchers at Duke University Medical Center who discovered the mutation.

杜克大学医学中心的研究人员声称，这项发现将带来药物的变革以针对该致病基因。

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The heavy teaching tasks and the defective research circumstances also affect their research ability development.

科研环境欠佳；教学任务繁重等。

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The theory is that the protein in sperm which triggers chemical changes in the egg, leading to embryo development, is defective or missing from the sperm of some infertile men.

BBC: Sea squirts aid fertility research