Unless there's a plea deal, the case is dismissed or there is another unexpected turn of events, the final decision of who is right and wrong will be made by jurors.

CNN: STORY HIGHLIGHTS

Prosecutor Giuliano Mignini, who investigated the original murder and defended the prosecution's case in the appeal, urged the jurors to make their decision on the basis of what they had heard in court, not in the overwhelming media coverage.

CNN: Amanda Knox: How the four-year court saga unfolded

The court also overruled Ito's decision to inform jurors that Fuhrman had taken the Fifth Amendment outside of its presence.

CNN: Tumultuous week as trial nears end