It has been reported recently,GRK can bind with nonreceptor substrates,except for phospholation and desensitization of GPCR,showing multiple functions.
近来的研究发现,GRK除了磷酸化受体使其脱敏外,还能与其他非受体底物结合,功能呈现多样性。
参考来源 - GRK在细胞周期和神经元发育中的作用Traditionally, nAChRs desensitization is viewed as a non-functional state.
传统观点认为,失敏态N受体是一种无功能状态。
参考来源 - 失敏态脑N受体药理学特征的研究The method of deep desensitization coating, which firstly coats RDX with wax then with polymer again, is able to decrease impact sensitivity to 0-12%.
对RDX采用石蜡内包,聚合物外包的深钝感包覆方法能够将其撞击感度降到0~12%的水平。
参考来源 - RDX的钝化和B炸药的改性研究The result showed that:1 Violent video games had the instant desensitization effect.
结果表明:1.暴力电子游戏可以产生即时脱敏效应。
参考来源 - 主动参与与被动观看暴力电子游戏即时脱敏效应的比较研究The desensitization of mGluR1 is in response to both GRKs and second-messenger-dependent protein kinases. Moreover, the desensitization of mGluR1 mediated by GRK2 appears to be both phosphorylation- andβ-arrestin-independent.
GRKs和第二信使依赖的蛋白激酶都能够介导mGluR1失敏,GRK2介导的mGluR1失敏不依赖于磷酸化和β-arrestin。
参考来源 - GRK2介导的mGluR5非磷酸化依赖失敏机制的初步研究·2,447,543篇论文数据,部分数据来源于NoteExpress
同义词: desensitisation
以上来源于: WordNet
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