Aldose reductase(AR) is key rate-limiting enzyme in polyol pathway,and it is the target enzyme for treatment of DM complications. Aldose reductase reduces excess D-glucose into D-sorbitol with the associated conversion of NADPH to NADP+.
醛糖还原酶(aldose reductase,AR)是多元醇代谢通路中的关键限速酶,是治疗糖尿病并发症的靶位酶,该酶以NADPH为辅酶,使葡萄糖还原为不易透过细胞膜的山梨醇,引起细胞的渗透性损伤,是糖尿病并发症发生的重要原因。
参考来源 - ARIs筛选模型的建立及相关药物的筛选·2,447,543篇论文数据,部分数据来源于NoteExpress
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