OBJECTIVE To develop a RP-HPLC method for the determination of clonazepam (CZP) in serum of drug-dependent patients to provide a scientific basis for clinical use of CZP.

目的建立测定药物依赖症患者血清中氯硝安定（CZP）浓度的RP—HPLC法，为临床用药提供依据。

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In repeated dose decreasing group, the CZP concentration ratio in both brain and serum declined to 0.7 with the dose decrease, almost the same as that of single-dose group.

减量重复给药后发现，随着第二次给药剂量减少，脑组织中药物浓度与血清药物浓度的比值下降至0.7，近似可接近单次给药后的比值。

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Objective To explore the effect of clonazepam (CZP) on background EEG activities and epileptiform discharges, and the relationship between the effects and the serum drug concentration.

目的了解氯硝西潘对脑电背景活动、样放电的影响，及其与氯硝西潘血清浓度的关系。

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