Conclusion CTLA, 4 gene seems to be a new susceptible candidate gene of GD in Cantonese Han population.

结论CTLA - 4基因可能是广东地区汉族人群中GD的易感候选基因。

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The enhanced cell surface expression of CTLA-4 is likely responsible for the induction of t cell anergy.

结论CTLA - 4表面表达水平的升高很可能与T细胞无能状态的诱导有关。

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Although the mechanism of signaling by CD28and CTLA-4has been well studied, many questions still remain to be answered.

在信号转导机制方面，对CD 28和CTLA - 4研究得比较多，但仍有许多问题未解决。

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The antibodies bind to the CTLA-4, found on a cell's surface, and shut off the brake.

FORBES: Magazine Article

In the mid-1990s he theorized that CTLA-4 might prevent the immune system from mounting an effective response against tumors.

FORBES: Targeting Melanoma

But Allison showed in 1996 that he could shrink tumors in mice by injecting them with antibodies to CTLA-4.

FORBES: Targeting Melanoma