The enhanced cell surface expression of CTLA-4 is likely responsible for the induction of t cell anergy.

结论CTLA - 4表面表达水平的升高很可能与T细胞无能状态的诱导有关。

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Objective To investigate the effect of astilbin on expression of CTLA-4 in activated T cells of mouse heart transplantation model with acute rejection.

目的探讨落新妇甙对混合细胞培养中活化的T细胞产生细胞毒T淋巴细胞相关抗原4（CTLA-4）表达的影响。

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Objective To investigate the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene A/G polymorphism with susceptibility to diabetes mellitus in Han Chinese.

目的探讨细胞毒T细胞相关抗原4 （CTLA 4 ）基因A/G多态性与汉族人糖尿病易感性的关系。

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The antibodies bind to the CTLA-4, found on a cell's surface, and shut off the brake.

FORBES: Magazine Article

In the mid-1990s he theorized that CTLA-4 might prevent the immune system from mounting an effective response against tumors.

FORBES: Targeting Melanoma

But Allison showed in 1996 that he could shrink tumors in mice by injecting them with antibodies to CTLA-4.

FORBES: Targeting Melanoma