Now the subject matter that he's chosen for this poem, for this so-called first poem, couldn't possibly be more appropriate.

现在他选这首诗的主题很重要，这所谓第一首诗可能不太恰当。

耶鲁公开课 - 弥尔顿课程节选

Gosh, the answer to that is, again, duh! No. You couldn't possibly survive your death, given the very definition.

答案当然是,不可能,你不可能死后逃生,这是毋庸置疑的

耶鲁公开课 - 死亡课程节选

Why didn't he come clean? Of course, they took "The Purloined Ribbon" to be his sort of allegorical way of suggesting that he couldn't possibly confess because nobody can confess, there's no human subjectivity, etc., etc., etc.

为什么不全盘招供，当然，人们把他写的“偷窃的缎带“当成他用一种讽喻的方式,来暗示说他不可能承认,因为没有人能承认，人类主观性的缺失，等等等等。

耶鲁公开课 - 文学理论导论课程节选

The firm was losing big deals to competitors because it couldn't price them right and was entering into contracts that couldn't possibly turn a profit.

FORBES: First, Heal Thyself

He complained but says his doctor told him the drug couldn't possibly be making him worse.

FORBES: Magazine Article

The shop was pursuing an experimental cancer therapy that many experts said couldn't possibly work.

FORBES: Targeting Tumors