功能性生物实验不可或缺的试剂 —— NA/LE 抗体 ... ① 功能性生物实验(Functional Assay) 包括:共刺激(Costimulation) 活化(Activation) ...
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Costimulation Model 协同刺激模式
Costimulation blockade 共同刺激通道阻断
CD28 molecule costimulation CD28分子共刺激
costimulation molecules B7-1 共刺激分子B
The competitive inhibition rate of anti-CD80-ScFv from murine parent antibody 4E5 was 98.67%,and anti-CD80-ScFv could make the proliferation rate of PBMC decline by 43.48% via blocking costimulation signal mediated by CD80.
抗CD80-ScFv对鼠源亲本抗体4E5与抗原结合的竞争抑制率达98.67%,并能阻断CD80介导的共刺激信号转导,抑制PBMC的增殖,增殖率下降43.48%。
参考来源 - 抗人CD80单链抗体的构建、表达及与抗原结合的特性分析·2,447,543篇论文数据,部分数据来源于NoteExpress
Objective: CD3AK cells were tumor-killing cells induced by costimulation of anti-CD3McAb and IL-2.
目的:cd3ak细胞是由抗cd3单克隆抗体和IL 2共同激活诱导的肿瘤杀伤细胞。
However, when the supernatant from CECs was concentrated and treated by acid activation, it exhibited the inhibitory effect of the thymocyte costimulation assays in dose-response way.
然而,当CEC培养上清经过浓缩和酸处理后,则在胸腺细胞共刺激实验中显示剂量-反应形式的抑制效应。
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