He well knew the futility of trying to contend against witches, so he gave up discouraged.

他深知与女巫斗争是徒劳无益的，所以他灰心丧气地放弃了。

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The firm is too small to contend against [with] large international companies.

这家公司太小，无法与国际性的大公司抗争。

《新英汉大辞典》

They had to contend against drought.

他们必须跟干旱作斗争。

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In an era where Danica Patrick can contend against men in motor sports, Silberman is about to take a big kick forward for female athletes, even if the odds are clearly stacked against her.

WSJ: Female kicker set for NFL regional combine tryout

Many also contend that inflation can work against fixed guaranteed withdrawal features.

FORBES: Aiming For Advisors

The ruling came from a panel of "special masters" who began hearing three test cases in 2007 involving children with autism -- a disorder that their parents contend was triggered by the vaccine against measles, mumps and rubella combined with vaccines containing thimerosal, a mercury-based preservative.

CNN: Vaccines didn't cause autism, court rules