I'll compute its value. Then I'll empty the backpack out, put another combination of stuff compute its value, try all possible ways of filling up the backpack, and then when I'm done, I'll know which was the best.
We know that if the entire sequester came out of FDA manpower, it would require a reduction in force of between 1000 and 1400 people (probably a combination of not filling vacancies, which is a really bad way to decide priorities, and lay-offs).