...标志物,以流行病学、治疗学、病理生理学和其他科学证据为基础,预期能预测临床获益或风险;(3)临床终点(clinical endpoint):指反映病人感觉、功能、生存的特征或变量。表1列出部分疾病的生物标志物和临床终点指标。
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The program allows the FDA to approve a drug to treat serious diseases with an unmet medical need based on an endpoint thought to reasonably predict clinical benefit.
该程序允许FDA根据一项被认为能够可靠预测临床疗效的(试验)终点来批准用于治疗目前医学无法满足的严重疾病的药物。
Clinical cure, the primary endpoint, was defined as a reduction of at least 75% on the Acute Bronchitis Severity Score at 14 days.
研究的基本终止点即临床治愈的评判标准为14天后至少75%的患者的急性气管严重度评分降低。
Objective To investigate the clinical value of endpoint detection of HBV-DNA by means of fluorescent quantitive PCR.
目的运用终点法荧光定量pcr检测HBV - DNA,探讨其临床应用价值。
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