For example, in patients with renal failure or chronic renal disease, we need to be very careful to reduce the dose of the drug by titration.

例如，肾衰或慢性肾病的患者，我们需要非常小心的逐步减少药物剂量。

youdao

FORTEKOR reduced erythrocyte counts in normal cats at high doses, but this effect was not observed at the recommended dose during clinical trials in cats with chronic renal insufficiency.

FORTEKOR减少在高剂量红细胞计数正常猫科动物，但这种影响并没有在推荐剂量与期间观察猫慢性肾功能不全的临床试验。

youdao

Amlodipine at therapeutic dose might be effective and safe for the treatment of chronic heart failure.

治疗剂量的氨氯地平是治疗慢性心功能不全较为理想的药物。

youdao

High-dose chronic pain medications are questioned by many pain physicians, and so long-term use of pain medications should be done judiciously and with expert supervision due to the risks associated with this form of treatment.

CNN: 5 ways to handle chronic pain

"The dose was fairly directly related to the amount of chronic sinusitis that people developed, " says David Arnold, M.

CNN: Sinus trouble? Secondhand smoke may be to blame