OBJECTIVE to synthesize and screen tropane derivatives with cholinergic activity and subtype-selectivity of M1 receptor.
目的设计、合成并筛选具有胆碱能活性，且对M1受体有选择性的莨菪烷衍生物。
Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS).
包括直接兴奋毒蕈碱受体的药物和(胆碱酯酶抑制剂)。
Conclusion: After vagus cholinergic m receptor was blockaded, the signal of puncturing Zusanli acupoint may regulate gastric activity probably via external SP peptidergic nerve passage.
结论：迷走胆碱能神经m受体被阻断后，针刺足三里信号可能通过外周SP等肽能神经调整胃功能活动。
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