Toynbee starts from suffering of civilization in his study on history and puts forward the theory of "Challenge and Response."

“挑战与应战”的原理是汤因比文明忧患论的积极发挥。

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Although the challenge to business method patents have never stopped, I believe the protection of business method patents is irreversible, we should face the challenge and response to it actively.

虽然对商业方法专利的质疑从未停止过，但笔者认为商业方法专利保护的国际潮流不可逆转，面对挑战，我国应积极应对。

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This is a grand challenge for our age and it may require an "irrational" response.

这是我们这个时代面临的重大挑战，为此可能需要“非理性”的回应。

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The community has large Hispanic and Vietnamese populations, which result in language barriers and cultural considerations that challenge our disaster response and community preparedness efforts.

WHITEHOUSE: Creating Community Resilience

What data do they have (opinions, needs, experiences, perspectives, etc.) that are relevant to the challenge and to my response?

FORBES: Magazine Article

Finally, the BP spill has presented an unprecedented challenge as an emergency environmental response and a long-term restoration effort.

WHITEHOUSE: Blog Action Day: Protecting America��s Waters Today