METHODS: The title compounds were synthesized by acylation of twelve acyl chlorides and two intermediates prepared by Friedel Crafts reaction, lengthening of carbon chain, hydrolysis and cyclization;

方法：通过付克反应、碳链延长、水解和环合反应得到两个关键中间体，然后通过酰化反应制得各种酰胺化合物；

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So the chain of title became crucial and the botched paperwork became a nontrivial issue.

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As generations pass and chunks of land get handed down to various offspring, following the chain of title can be difficult indeed.

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