Orthogonal design expeirimentsuggested that the order of influence is reaction temperature、ratio ofcefalotin to methoxyl sodium,reaction time,ratio of Cefalotin to NBS. Theoptimum condition that reaction temperature is -60℃,ratio of Cefalotin:NBS) is 1:1.5,ratio of cefolotin:methoxyl sodium is 1:25,reaction time is 6hours.
最佳反应条件为:反应温度为-60℃、头孢噻吩与NBS的比例1:1.5、头孢噻吩与甲醇钠的比例=1:25、反应时间为6小时。
参考来源 - 头孢西丁钠的合成·2,447,543篇论文数据,部分数据来源于NoteExpress
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