Secondary caries occurs on the edge of the restoration. It is the major reason for replacing restoration and causing failure of treatment in clinic.

继发龋是龋病治疗后再度发生的龋损，是迄今为止临床上充填体更换和失败最常见的原因。

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Since the disease almost always kills, usually by causing kidney failure, the patients had little hope.

FORBES: Magazine Article

It means some computers could interpret '00' as 1900 instead of 2000, causing system failure or unpredictable behaviour.

BBC: UK opens Y2K bug website

The second compared Vytorin to a placebo, leaving open to interpretation whether it was Zocor alone or the combination that was causing the failure.

FORBES: Merck's Big Vytorin Study Could Change Rules For New Cholesterol Drugs