The catalytic cycle of the reaction was proposed based on experiment results.

根据实验的结果建议了反应的催化循环机理。

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Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2, 3).

依托泊苷能稳定酶催化性循环中的一种共价的拓扑异构酶ii裂解的DNA中间复合物，导致基因组不稳定性和细胞死亡(2,3)。

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According to the control experiments and the experiment phenomena, a possible catalytic cycle and a possible key intermediate are rationally proposed to illustrate the experimental observations.

根据对比实验以及实验现象，提出了可能的催化循环和反应过渡态。

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