To some degree, this transformation has felt disruptive all along. But the pace of the change has quickened since the turn of the millennium, and even more so since the crash.
这种转变看起来像是一直具有某种破坏性，但是迈入新千年后它的步伐却加快了，而且在大萧条后变得更快了。
The treatment of CML evolved slowly at first, but the pace has quickened in the past 20 years.
起初，对CML的治疗进展缓慢，但近20年来却取得了长足的进步。
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