He had [suffered] a setback in his business.

他在生意上遭到挫折。

youdao

This is just a minor setback in a major operation! As soon as I whip up another spell, we'll be back in business!

这只是一个小小的失误一旦我重施咒语，一切都会好起来的！

youdao

But the billionaire American investor is now trying again, making a second investment in the company that dealt him his biggest business setback.

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In the real world of business, setback and failure require reflection and recalibration, processes that are hindered by the exaggerated behavior of a leader.

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Since its creation in 1992, the PTC has expired on three occasions, each a big setback for the wind business.

FORBES: Magazine Article