当囊壁较厚时,药物的释放可分为4个阶段: ①初期的突释(burst effect) :来自微囊外表面药物; ②慢速释放:来自囊内的药物透过囊壁扩散; ③较快速的稳态扩散释放:来自囊内的药物饱和溶液, 维持时间最长...
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After desalination of inner water phase, the particlesize was smaller; the number of microspheres decreased; the density of microspheresincreased; burst effect of microspheres significantly decreased.
内水相脱盐后,可使制备的微球粒径和数目减小,密度增大,突释效应显著降低。
参考来源 - 重组人干扰素α长效注射微球的研究·2,447,543篇论文数据，部分数据来源于NoteExpress
The pattern of drug release for 30 days in vitro fitted to zero order release plot, with an initial burst effect at the first day.
体外释放第一天呈突释效应，而后药物释放基本符合零级动力学过程。
After a initial transient, "burst effect", the drug was released continuously from the device at a constant rate for a long period of time.
本给药系统在“漏槽”状态下测定释放速度，经短时间的较快释放后可维持长期的零级速度。
New imported food grade SUS304 stainless steel shell design, high strength, not burst, deformation, leakage prevention effect is good, environmental protection, safe and durable.
全新进口食品级SUS304不锈钢外壳设计，强度高、不爆裂、不变形、防漏效果好、环保、安全、经久耐用。
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