The preparation methods of high purity and high yield of p-bromophenol and 2,4,6-tribromophenol by selective orientation bromination of phenol were studied.
通过控制反应条件,让溴素对苯酚进行有选择性的定位溴化,分别生成高纯度、高收率的对溴苯酚和三溴苯酚。
参考来源 - 苯酚一元溴化的定位效应研究·2,447,543篇论文数据，部分数据来源于NoteExpress
Adapalene was synthesized from 4-bromophenol by alkylation, etherification, condensation and hydrolysis with an overall yield of 51%.
对溴苯酚经烷基化、硫酸二甲酯醚化、缩合及水解反应制得阿达帕林，总收率51%。
Content of the products were quantitatively determined by two-phase chemical titration using bromophenol blue as the indicator and dichloroethane as the phase splitting agent.
以溴酚蓝为指示剂、二氯乙烷为分散相两相化学滴定法测定产物的含量。
The bromophenol compounds of the invention have inhibitory activity against protein tyrosine phosphatase (PTP1B), and can be used for treating the type 2 diabetes and the obesity.
本发明中的溴酚类化合物具有蛋白质酪氨酸磷酸酯酶(PTP1B)抑制活性，可用于治疗2型糖尿病和肥胖症。
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