Lo said that while his team was studying resistance, they expected to find secondary mutations in BRAF.

Lo说，虽然他的团队在研究耐药性，但是他们却希望存在BRAF的二次变异。

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Mutational activation of the BRAF oncogene is the most common genetic alteration in cutaneous melanoma.

BRAF癌基因突变的激活是皮肤黑色素瘤最常见的基因改变。

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About half of all melanoma patients have a mutated BRAF gene. This mutation tells the cell to continue to grow.

将近半数的黑色素瘤患者都有BRAF基因突变，从而导致黑色素肿瘤细胞继续生长。

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The drug so far has only helped patients whose tumors have the BRAF mutation.

FORBES: American Society of Clinical Oncology

Prof Richard Marais, from the Paterson Institute for Cancer Research in Manchester, was involved in the discovery of the BRAF fault.

BBC: 'Drug holidays' beat cancer drug resistance in mice

In 2002 gene researchers in the U.K. discovered that two-thirds of melanomas have a mutation in a growth-promoting gene inside skin cells called BRAF.

FORBES: Targeting Melanoma