They are very similar in structure, but different in tissue distribution, expression in different tissues and biological effects after binding to ligand.

两种亚型在结构上有高度的同源性，但是组织分布和各组织成分中的表达明显不同，与配体结合后产生的生物效应也不同。

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The purpose of the paper is to build a module of small molecular receptor fragments charactering normal VLDL-R binding function and study the mechanism of VLDL-R binding to ligand.

建立具有正常极低密度脂蛋白（VLDL）受体结合功能的小分子受体片段模型并借助此模型研究VLDL受体与配体结合的作用机制。

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The protein has multiple subunits, each with a single ligand-binding site. Binding of ligand to one site decreases the binding affinity of other sites for the ligand.

此蛋白质有多个亚基，每个亚基上有一个结合位点。配体与一个结合位点的结合降低了其它位点对配体的亲和力。

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There's a diverse range of responses that might occur, but that response is initiated by this simple chemical process of a ligand binding to a receptor.

细胞对外界信号可能会发生不同的反应,但这些反应都源自,配体和受体结合这个简单的化学过程

耶鲁公开课 - 生物医学工程探索课程节选

It gets produced in response to a signal so there's a binding of a ligand to a receptor, the enzyme that does this conversion is activated and more cycle AMP is released.

这类分子的产生是对信号做出的一种反应,当配体和受体结合时,催化这种转化过程的酶被激活,更多的cAMP释放出来

耶鲁公开课 - 生物医学工程探索课程节选