Her departure is a big loss to the school.

她这一走对学校来说是一个巨大的损失。

《牛津词典》

youdao

If she leaves, it'll be a big loss to us.

如果她离开，对我们来说将是一个巨大的损失。

youdao

"We are really sad that he is no more with us," "Many pop singers, like all our pop singers, they have some kind of influence and they,to some extent, have followed his ideas and compositions, and so it's a big time loss."

VOA: standard.2009.06.26

Bank B is stuck with a big loss it thought it was insured against.

FORBES: Greek Election: Does It Matter?

Depositors with more than 100, 000 euros in the bank are now facing a big loss.

BBC: Key data missing at troubled Bank of Cyprus - inquiry

The ITC tossing out yet another complaint is a big loss for Motorola and Google.

ENGADGET