This was my big chance and I grabbed it with both hands.

这是我的大好机会，我紧紧抓住。

《牛津词典》

This is his big chance, and you're making it possible.

这是他的大好机会，而你们正在使之成为可能。

youdao

Here's your big chance!

现在你的机会来了！

youdao

Lee took a big chance.

VOA: special.2009.09.17

If people want to take the chance or if people want to live big today and live a poor retirement, that should be their choice.

如果人们想要碰运气,或今朝有酒今朝醉,哪管退休喝凉水，那也是他们的选择。

耶鲁公开课 - 公正课程节选

I'm just going to be paying back my debts and go bankrupt, so I'll take a big gamble and then at least I have a one in three chance of making money.

那样我就会因为要还债而破产,所以我要赌一把,至少有三分之一的机会能赢钱

耶鲁公开课 - 金融市场课程节选

"It's been a great day for us and we've got a big chance, " added Ferguson.

BBC: Ferguson piles stress on Chelsea

"We have a big chance to become the first holders of the Confederation Cup, " said Schmidt.

BBC: SPORT | Football | African | 'Only a miracle can save Hearts'

Debt Fund is taking the big chance that the cheap securities will rebound.

FORBES: Nation Building