Amyloid plaques form when a molecule called amyloid precursor protein (APP) is chopped up by two enzymes known as beta-secretase and gamma-secretase.

当一种叫淀粉样前体蛋白（APP）的分子被两种酶——分别叫作贝塔-分泌酶和伽玛-分泌酶——切断时就形成了淀粉样斑块。

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The causes for Alzheimer's disease are not known, but dysregulation of amyloid-precursor protein expression and beta-amyloid clearance is hypothesized (beta-amyloid cascade).

虽然导致老年痴呆症的原因还没有发现，但是有人假设其原因是淀粉样前提蛋白的调节异常和β-淀粉样蛋白的消失（β-淀粉样蛋白连锁反应）。

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To be specific, Merck (MRK) will test a beta-amyloid precursor protein site-cleaving enzyme, or BACE, inhibitor, which the drugmaker notes is the first drug with this type of mechanism to advance to this stage of clinical research.

FORBES: Merck Makes A 'Speculative' Step Into Alzheimer's