I shall be profoundly grateful if you will give me an early answer.

如果你能及早给我答复，我将十分感激。

youdao

And as a daughter, I'll be profoundly grateful to my parents, knowing that I am here only because of their lifetime of faith and hard work.

作为女儿，我会深深地感谢我的父母双亲，我知道，正是由于他们坚持一生的执著信念和辛勤劳作，我才能够站在这里。

youdao

"I don't even have the words to say how profoundly grateful I am for more than a quarter of a century to be your teammate, " said Clinton, reminiscing about union donations and support during his unsuccessful 1974 congressional campaign -- his first bid for public office.

CNN: Clinton offers 'thank you' for union support