Suicide gene includedin virus or bacterial genome, encodes special enzyme. Nontoxic prodrug can bemetabolized by the latter, become venenous production and make cell died.
众多学者关注的自杀基因治疗是利用基因工程技术将一些病毒或细菌基因组中前药转换酶基因(也叫自杀基因)导人肿瘤细胞,该基因编码特殊的酶,可使原先对哺乳动物细胞无毒性的前药在肿瘤细胞中代谢为毒性产物,从而引起这些细胞的死亡,所以又称为“病毒导向的酶解前药疗法”或“分子化疗”。
参考来源 - 基因重组HSV·2,447,543篇论文数据,部分数据来源于NoteExpress
Now he has a bacterial genome in his sights.
现在,他又瞄准了细菌基因组。
This is the first time a native bacterial genome has been grown successfully in yeast.
这是第一次原生细菌的基因组在酵母中也成功地复制。
Dr Venter reckons he will be able to synthesise a working bacterial genome from scratch within two years.
Venter博士估计他可以从零做起,在两年内合成一个可以工作的细菌基因组。
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