METHODS:Guinea pigs were divided into 5 groups: the normal control group, the asthma model group, the continued asthma model group, histamine group and histamine receptor antagonist group.

方法：将豚鼠分为正常对照组、哮喘模型组、哮喘模型延续组、组胺组、组胺受体拮抗剂组。用高效液相色谱法检测血清组胺浓度；

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Methodes: The rat model of asthma were randomly divided into three groups, including asthma group (group a), control group (group c) and dexamethasone treated group (group d).

方法：采用大鼠哮喘模型，随机分成三组：哮喘组(a组)、正常对照组(C组)、地塞米松治疗组(D组)。

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Conclusion: CVA model of guinea pig airway responsiveness in pathological changes were lower than the level measured in guinea pig asthma model, and higher than the normal control group.

结论：豚鼠cva模型的气道高反应性、病理改变均低于豚鼠哮喘模型，并高于正常对照组。

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