"Our approach opens up a completely new avenue for therapy, " says Dr. Wisniewski. "There is a lot of data showing that apo E is important in sporadic Alzheimer's disease.

Wisniewski说，我们的方式为治疗这种疾病开拓了一种全新的途径，大量的数据表明载脂蛋白E在散发阿耳茨海默氏病起重要作用。

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Apo-E is thought to stop the damage being done to the cholesterol, but with varying degrees of effectiveness.

BBC: Gene linked to heart disease risk

Among both Finns and French, people born with an apo E-2 gene have a four-fold greater likelihood of reaching 100 than those born with an apo E-4, the studies find.

WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live

Zannis, first discovered 17 years ago that there were three versions of apo E, they found that most people afflicted with a rare type of artery-clogging atherosclerosis had two copies of apo E-2.

WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live