并且,在DQB和MHC-I基因座位的假定的抗原结合位点(Antigen binding sites,ABS),非同义替代明显大于同义替代,提示平衡选择(Balancing selection)维持这两个座位的...
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The substitutions of amino acid tended to gather around the putative antigen-binding sites.
氨基酸的替换趋于集中在假定的抗原结合位点附近。
Well, one way to think about is they have more antigen binding sites and so they're going to be more efficient at neutralizing the pathogen on a per-molecule basis than IgG is.
可以这么考虑,因为IgM表面有更多的抗原结合位点,所以相对于IgG,IgM在分子层面上,能够更为有效地与病原体结合
The advantage of this is that now you have four binding sites for antigen instead of just two.
这样的好处是一个抗体上,有四个抗原结合位点而不仅仅是两个
So, these are better at binding to antigen because they have more binding sites on them.
连接抗体是对付抗原的有效方法,因为抗体表面将会有更多的抗原结合位点
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