The immunogenicity of 12F6 in humans has been reduced though humanization. But the first-dose reaction associated with T cell activation by anti-CD3 Abs still exists.

人源化抗体解决了抗体鼠源性的问题，但CD3单抗激活T细胞引起首剂效应的问题仍然存在。

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Objective: To study bidirectional binding ability and immunoactivity of anti-CD3/anti-glioma bispecific antibodies(BsAb) , and to study its effect on T lymphocytes cells.

目的：鉴定自制的抗CD3-抗胶质瘤双特异性抗体（双抗）的双向结合能力，测定其免疫活性及其对T淋巴细胞的作用。

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Using anti-CD3 and anti-CD28 to mimic stimulatory signal I / II, to study their function of activing T cells in order to explore the possible mechanism of immune up and down regulation.

利用CD3/28双抗体模拟第一、二信号的变化探讨免疫上下调节的可能机制，为我们研究输血带来的免疫影响及如何纠正提供可依靠的线索。

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Osiris Therapeutics is testing in new diabetics an adult stem-cell therapy that it hopes will have fewer side effects than anti-CD3 drugs.

FORBES: Magazine Article

Privately held biotech firm Tolerx, allied with GlaxoSmithkline, aims to begin, by summer, a final-stage trial of its anti-CD3 drug, otelixizumab, in 250 newly diagnosed adults.

FORBES: Delaying Diabetes

Osiris Therapeutics (nasdaq: OSIR - news - people ) is testing in new diabetics an adult stem-cell therapy that it hopes will have fewer side effects than anti-CD3 drugs.

FORBES: Delaying Diabetes