This ability to persevere despite obstacles and setbacks is the quality people most admire in others.

这种不管障碍和挫折的锲而不舍的能力是人们最为钦佩的品质。

《柯林斯英汉双解大词典》

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Sure they experienced numerous obstacles and setbacks and failures.

当然他们遇到大量的障碍和挫折和失败。

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Europe is poised to undergo dramatic structural changes, after years of discussions and setbacks.

VOA: standard.2009.10.29

And it is holding up over years, despite casualties and setbacks."

VOA: standard.2009.09.29

Now, Lyrica has been beset by delays and setbacks that could damage its value.

FORBES: Pfizer's Disappointing Victory

Despite difficulties and setbacks, Millhone is up to the task of warming up long-cold trails.

FORBES: Fact and Comment

And there are going to be false starts and setbacks and mistakes along the way.

WHITEHOUSE: White House Forum on Health Reform