They become angry, unhappy, sad and lonely.

他们变得愤怒、不悦、难过而孤独。

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They feel irritable and depressed, often isolated and lonely.

他们感到烦躁和抑郁，经常感到孤立和孤独。

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Yet they can be cold and lonely in the winter.

VOA: special.2010.05.30

It just doesn't seem true that everybody who knows they're going to die and is facing their death feels lonely.

说每个知道自己就要死亡的人,会觉得孤独这也不对。

耶鲁公开课 - 死亡课程节选

And yet,for all that,feels removed,distant, alienated from the others,feels lonely even in the crowd.

但还是感觉非常疏远，有距离感，感到和他人疏远，在人群中都觉得孤单。

耶鲁公开课 - 死亡课程节选

Luckily for you, there are thousands of other entrepreneurs who also feel isolated and lonely.

FORBES: Starting Up? Embrace Your (Sometimes Scary) New Normal

Feeling isolated and lonely is also known to have an impact on physical and mental health.

BBC: Fears over health and loneliness of elderly this winter

Sometimes I see myself sad and lonely, but I think I deserve to be more happy.

CNN: December 17, 2012 -- Updated 1437 GMT (2237 HKT)