I am filled with tremendous sadness and remorse.

我的心中充满了悲伤与懊悔。

youdao

The weeks that followed were filled with sadness and frustration.

接下来的几周都充满着悲伤和沮丧。

youdao

I can't remember a public event that filled me with more deep sadness and despair.

我记不起还有哪一次公共事件能比9•11更令我悲伤和绝望。

youdao

Vincent Van Gogh's life was filled with sadness and struggles.

VOA: special.2010.03.24

It was filled with surprises,tragedy, violence and sadness.

VOA: special.2009.08.30

There were times when the idea of parting from his mother filled Aryeh Zelnik with sadness and shame, but there were other times when he almost looked forward to her decline and to the possibilities that would open up before him when she was taken out of the house.

NEWYORKER: Heirs

The little girl whose life was filled with a sadness she never put into words, and who stopped going to school because the children laughed at the way she walked, was suddenly the head of the family.

BBC: Marwa's story: 10 years since the bomb fell