Especially when the time path is a highly non-linear, the polynomial rules become very complex and difficult to operate.

特别是当时间路径为高度非线性时，多项式法则变得很复杂且很难操作。

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In the process of the introduction of classical problem based learning, the combination of PBL teaching method and current teaching method was found to be abstract and difficult to operate.

将国外经典PBL教学模式引入临床教学过程中，发现经典PBL教学模式与目前教学模式结合起来时存在抽象、操控难度大等问题。

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Because it is difficult to trace hackers, exactly who isbehind any specific attack and how and where they operate remains to alarge extent a mystery, technology experts say.

技术专家说，因为黑客很难追踪，所以谁是攻击的幕后黑手很难确定，他们在哪里以及如何发动的攻击在很大程度上也都是谜。

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Imagine how much power it takes to drive an artificial heart, so you've got to have a battery or some way of generating power continuously to operate that and that makes it difficult to think about implantable and so that's a really good example of Biomedical Engineering.

驱动人工心脏所需要的能量是难以想像的,所以需要电池或者是某种持续发电装置,来给人工心脏提供能量,这就增加了人工心脏的植入难度,这是很好的生物医学工程的例子

耶鲁公开课 - 生物医学工程探索课程节选

Even as the ice recedes, the Arctic will remain extraordinarily cold, dark, remote, expensive and difficult to operate in.

ECONOMIST: Climate change

Most computers were expensive and difficult to operate, and would typically be hard-wired directly to another computer if a connection was needed.

ECONOMIST: CASE HISTORY: Out of the ether | The

Upon taking his position, Root stepped in and altered some of the new design, getting rid of such fixtures as Vichy showers, which can be expensive to operate and difficult to explain to spa novices, and severely limit a room's flexibility.

FORBES: The Old South rises again at the Spa at Sea Island, Georgia.