Using 2-aminopyridine as raw material and via nitrification,amino acetylation,reduction of nitro,diazolization,Schiemann reaction and hydrolysis of acetyl,a novel synthesis route of 2-amino-5-fluoropyridine was proposed.
Post-translational modifications usually occur as chemical modifications at amino acidresidues, includingSUMOylation, phosphorylation, palmitoylation , acetylation, etc.