In 2007, the International Agency for Research on Cancer (IARC) reclassified working at night from a possible to a probable (group 2A) human carcinogen. Working night shifts disrupts the circadian system, alters sleep patterns, induces chronic sleep deprivation, and suppresses the production of melatonin (an antioxidant and tumour suppressor). Breast cancer, however, is associated with raised concentrations of oestrogen, which is overproduced under artificial light and suppresses melatonin production.
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