abstract:Afterdepolarizations are abnormal depolarizations of cardiac myocytes that interrupt phase 2, phase 3, or phase 4 of the cardiac action potential in the electrical conduction system of the heart. Afterdepolarizations may lead to cardiac arrhythmias.
Conclusion: (1) The ischemiaor reperfusionarrhythmiascould be suppressed by pinacidil preconditioningandmechanismmay relate to eliminate early afterdepolarization (EAD).