This work was mainly focused on the transcriptional regulation of human ACAT-1 gene P7 promoter activity, and the effect of fatty acids on human ACAT1 gene expression.

本论文工作着重进行人acat - 1基因P 7启动子活性调控和脂肪酸对人acat 1基因表达影响的两部分探索。

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Objective: To investigate the role of taurine in acyl-coenzyme a: cholesterol acyltransferase-1 (ACAT-1) expression and activity in THP-1 and THP-1-derived macrophages.

目的：观察牛磺酸对THP - 1及THP - 1源性巨噬细胞酰基辅酶a：胆固醇酰基转移酶1 (ACAT - 1)表达及活性的影响。

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Acyl-CoA: cholesterol acyltransferase(ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from long-chain fatty acyl coenzyme A and cholesterol.

酰基辅酶A：胆固醇酰基转移酶（ACAT）是细胞内唯一合成胆固醇酯的酶，在细胞和生物体胆固醇代谢平衡中起非常重要的作用。

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These medicines, called acyl-CoA cholesterol acyl-transferase (ACAT) inhibitors, aim to prevent plaque from sticking to the walls of the arteries.

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Second, the testimony that every single client on the list of customers to whom he sent an overnight package requested the enclosed ACAT forms strains credulity (particularly since most of these customers did not actually transfer their accounts).

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Pfizer had aimed to develop its own ACAT inhibitor, but the drug failed to show a benefit. (See: Pfizer's Cardiovascular Failure) But some of the problems with that drug may have come from the fact that it interacted with Lipitor, preventing cholesterol from being lowered enough.

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