In one study, the average weight loss for a group taking a higher dose (32 mg) of naltrexone plus bupropion for about a year was 6.1% while for a lower dose (16 mg) it was 5%. (People taking a placebo had an average weight loss of 1.3%.) However, only half the participants who started the trial actually finished it.
There have, since then, been some discussions (most notably by Technologizer and MG Siegler himself) about the seeming decline in the quality of some of the comments -- but I'm going to leave that aside for the moment, and talk about the larger issue in all of this that interests me far more.