Boyd hobbled off early in the second half after failing to recover from atwistedankle suffered in the opening 45 minutes and Nacho Novo took his place up front.
Wilkinson is now off crutches in his recovery from atwistedankle but is still a major doubt, meaning Olly Barkley, man-of-the-match against the Americans, will almost certainly retain the number 10 jersey.
It was proving a thoroughly professional European display from the Dutch giants and matters took a turn for the worse for the hosts when Jermaine Jenas was stretchered off with atwistedankle.