The amount of fuel that this car uses is a big strike against it.

耗油量大是这辆车的一大缺点。

《牛津词典》

The harsh truth is that luck plays a big part in who will live or die.

残酷的现实是，运气在很大程度上决定着谁生谁死。

《柯林斯英汉双解大词典》

The fact that I was a foreigner was a big disadvantage.

我是外国人这事实对我十分不利。

《牛津词典》

A news report,for example, might say that people in Washington were battening down the hatches for a big winter storm.

VOA: special.2009.05.24

So that's a big help. And equilibrium happens when there isn't any possible change of state that would satisfy this.

这个非常方便，当所有的变化,都无法满足这个公式的时候,系统就达到了平衡。

麻省理工公开课 - 热力学与动力学课程节选

Oh really? I imagine that it must be very difficult to drive in a big city like New York.

是吗？在大城市开车肯定会比较困难，比如在纽约。

Do you ever实战 - SpeakingMax英语口语达人

So a veteran player, even an iconic one, might want to accept the fact that a final big score that carries past his 40th birthday may be a thing of the past.

FORBES: Tulo is the Future, not Jeter

And a big part of that, a big part of our future has to be a robust and growing manufacturing sector.

WHITEHOUSE: The Critical Role of Manufacturing

Creating retirement income that lasts a lifetime is a big aspect of that, but if we focus on finances alone, we come up short.

FORBES: Retirement: Prepare For Monumental Change