Because I grew up in a dysfunctional family, anger is a big issue for me.

我是在一个不正常的家庭里长大的，所以乱发脾气是我的一大问题。

《牛津词典》

When you want to study ancient human and Neanderthal remains, there's a big issue of contamination with contemporary human DNA.

当你想要研究古人类和尼安德特人的遗骸，一个大问题是当代人类的 DNA 受到的污染。

youdao

This is a big issue ; we need more time to think about it.

这是个重大问题，我们需要花较多的时间考虑。

《牛津词典》

And that's become a big issue. Not necessarily because of the location, but because of the security measures that have been taken.

VOA: standard.2010.02.17

But whenever we've had a reform era there's been a big issue, or two or three or four.

但每当我们有一个改革的时代,都会存在一个,两个,三个或者四个大问题

耶鲁公开课 - 美国内战与重建课程节选

That's a big issue. You can fix one thing, you break something else.

你可以解决一个问题，但你破坏了其它的程序。

麻省理工公开课 - 计算机科学及编程导论课程节选

"People being able to hack into the car is a big issue, " says Bergquist.

BBC: 'Every new car' connected to web by 2014

And so the water is over-allocated, and that's a big issue in the West.

NPR: Can Climate Change Explain Odd Weather?

Race is a big issue in Singapore, and few know that better than the PAP leadership.

CNN: The Ruling Party vs. Tang