The strongest expression was observed in pituitary,cartilage and gonad,whereas the lowest was seen in spleen,thymus and lymph,suggesting that Sox9 protein plays important roles in porcine gonad,brain and chondrogenesis development function.
在性腺和脑组织表达水平最高,而在脾、胸腺、淋巴组织表达水平最低,说明了Sox9基因在猪性腺、脑的发育以及软骨发生的功能与作用。
参考来源 - 猪Sox9基因cDNA的全长克隆及功能预测·2,447,543篇论文数据，部分数据来源于NoteExpress
MMP - 3在髁状突软骨发生退行性病变中起着重要作用。
MMP-3 plays an important role in the condylar cartilage injury and degeneration.
结论在骨关节炎中MMP 1、2、3和TIMP 1、2表达异常，引起细胞外基质异常降解，是导致关节软骨发生组织学退变的原因之一。
Conclusions The abnormal expressions of MMP? 1, 2, 3 and TIMP? 1, 2, which resulted in degradation disorder of extracellular matrix, could induce degeneration of cartilage.
当原纤维遭到破坏或者缺失就像混凝土缺少钢筋一样，骨性关节炎就会发生。软骨的机械性变弱易于磨损和撕裂。
Osteoarthritis occurs when the fibrils are disrupted or lost - just like concrete without the steel, the cartilage becomes mechanically weak and susceptible to wear and tear.
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